杨昭

发布时间:2019-10-31

姓名:杨    

职称:副教授

邮箱:yangzhao@mail.buct.edu.cn

办公地址:化新楼B312



教育背景:

2010.9-2015.6     中国科学院生物物理研究所学院,博士(生物化学与分子生物学专业)
 2006.9-2010.6     
吉林大学生命科学学院,学士(理科试验班专业)


工作经历:

2018.9-至今  足球外围平台,副教授

2015.7-2018.8  中国科学院微生物研究所,助理研究员


学术兼职:

1Cancer+杂志副主编(http://www.cancer.whioce.com/index.php/cancer

2)中国生物工程学会青年工作委员会委员

3)北京肿瘤病理精准诊断研究会常委


主要研究领域:

1.肿瘤标志物与肿瘤抗体药物

2.肿瘤干细胞

3.肿瘤免疫治疗


科研项目:

1. 2020-2024 前沿生物技术重大风险防范与化解研究国家社会科学基金重大项目 (项目参与人)

2. 2019.10-2022.09 可视化干细胞靶向肿瘤治疗技术用于肿瘤精准诊疗研究京津冀基础研究合作专项 (子课题负责人)

3. 2019.01-2021.08 新型CRISPR-Cas12a结构与功能研究中央高校基本科研业务费项(项目负责人)

4. 2017.7-2021.12 膀胱尿路上皮组织干细胞突变特征与演化研究国家重点研发计划(项目骨干)

5. 2017.01-2019.12 甲基转移酶KMT1A抑制剂的筛选及其靶向抑制膀胱癌干细胞的机制研究国家自然基金青年科学基金项目(项目负责人)

6. 2015.1-2018.12 长链非编码 RNA lncAC1 调控膀胱癌干细胞自我更新的分子机制研究国家自然基金面上项目(项目参与人)

7. 2014.1-2018.12 GALNT1介导的Hedgehog信号调控膀胱癌干细胞自我更新机制研究国家自然基金重点项目(项目参与人)


代表性论文:

1. Zhao Yang# , Kun Zhang, Tianying Xing, Suhang Bai, Zongyi Shen, Luyao Wang, Lingzhi Wan, Zichen Zhang, Chong Li, Wei Zhang. Application of Clustered Regularly Interspaced Short Palindromic Repeat-Cas12a System in Cancer Research and its Structural Basis. Cancer+. (2019) 1(3):1–6

2. Zhao Yang# , Haifeng Wang#, Suhang Bai, Zongyi Shen, Bo Zhong, Qiuyun Yan, Dongxiao Cheng, Wei Zhang, Jian Zhuang , Lingzhi Wang, Xinlu Yu, Fuhan Zhang, Ruonan Gao, Yuhan Yan , Changyuan Yu, Chong Li. LncRNA and gene expression profiling of human bladder cancer. Cancer+. (2019) 1(1):1-7

3. Zongyi Shen, Maochen Li, Suhang Bai, Qingkun Yang, Fuhan Zhang, Mao Tang, Jiangyu Guo, Zhao Yang. Advances in liver cancer immunotherapy. Chinese Journal of Biotechnology, 2019,35(12):2326-2338.

4. Suhang Bai, Xiaoyue Yang, Nan Zhang, Fuhan Zhang, Zongyi Shen,Na Yang, Wensai Zhang, Changyuan Yu, Zhao Yang. Research progress on the role of tumor infiltrating lymphocytes in solid tumors. Chinese Journal of Biotechnology, 2019,35(12):2308-2325.

5. Hongwei Su#, Tao Tao#, Zhao Yang#, Xing Kang, Xu Zhang, Danyue Kang, Song Wu and Chong Li. Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression. Mol Cancer. 2019, 19;18(1):27.

6. Zhao Yang#, Ruiyun Zhang#, Yunxia Ge, Xuying Qin, Xing Kang, Yue Wang, Xu Zhang, Chengli Song, Xiaofang Quan, Haifeng Wang, Haige Chen and Chong Li. Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy. EBioMedicine. 2018, 35:198-203.

7. Zhao Yang, Luyun He, Kaisu Lin, Yun Zhang, Aihua Deng, Yong Liang, Chong Li and Tingyi Wen. The KMT1A-GATA3-STAT3 circuit is a novel self-renewal signaling of human bladder cancer stem cells. Clin Cancer Res. 2017, 1;23(21):6673-6685.

8. Chong Li#, Song Wu#, Zhao Yang#, Xiaolong Zhang#, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li. Single-cell exome sequencing identifies KCP, LOC440040, and LOC440563 as driver genes in renal cell carcinoma stem cells. Cell Res. 2017, 27(4):590-593.

9. Zhao Yang#, Chong Li#, Zusen Fan#, Hongjie Liu#, Xiaolong Zhang#, Zhiming Cai#,Liqin Xu, Jian Luo, Yi Huang, Luyun He, Chunxiao Liu and Song Wu. Single-cell sequencing reveals variants in ARID1A, GPRC5A and MLL2 driving self-renewal of human bladder cancer stem cells. Eur Urol. 2017,71(1):8-12.

10. Chong Li#, Song Wu#, Zhao Yang#, Xiaolong Zhang#, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li. Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells. Cell Res.  (2017) 27:590-593.

11. Zhao Yang#, Shengwu Liu#, Mingao Zhu, Hong Zhang, Ji Wang, Qian Xu, Kaisu Lin, Xiumin Zhou, Min Tao, Chong Li and Hong Zhu. PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. Sci Rep. 2016, 26;6:22090.

12. Chong Li#, Ying Du#, Zhao Yang#, Luyun He, Yanying Wang, Lu Hao, Mingxia Ding,

Ruping Yan, Jiansong Wang, and Zusen Fan. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 1;76(5):1273-83.

13. Buqing Ye#, Chong Li#, Zhao Yang#, Yanying Wang, Junfeng Hao, Li Wang, Yi Li, Ying Du, Lu Hao, Benyu Liu, Shuo Wang, Pengyan Xia, Guanling Huang, Lei Sun, Yong Tian and Zusen Fan. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 17;211(12):2439-54.

 

代表性著作:

1. 抗体工厂,天津科学技术出版社,20186

2. 非编码RNA与肿瘤,天津科学技术出版社,20186

3. 细胞信号通路,天津科学技术出版社,20186

4. Essentials of Tumor-Related Genes (肿瘤相关基因概要)(上、下),天津科学技术出版社,20178

5. 膀胱癌基础与转化医学研究论文汇编,天津科学技术出版社,20178


教师寄语:

盛年不重来,一日难再晨。及时宜自勉,岁月不待人。


招生要求:

乐观开朗,笃行务实;

善于思考、善于沟通、善于合作;

作对科研有浓厚兴趣,执行能力强。