申晓林

发布时间:2019-10-31

姓名:申晓林

 

职称:讲师

 

邮箱:shenxl@mail.buct.edu.cn 

         

办公地址: 科西311


教育背景:

2009/09 – 2013/06,足球投注,足球外围平台,博士

2011/02 – 2012/05,University of Georgia,生命科学与农业系,联合培养博士

2006/09 – 2009/07,足球投注,足球外围平台,硕士

2002/09 – 2006/07,华中科技大学,足球外围平台,学士


工作经历:

2013.7-今  足球外围平台,讲师,硕士生导师


学术兼职:

中国生物工程协会青年工作委员会委员

担任 Microbial Cell Factory、 Scientific reports、Plos One、Applied microbiology and biotechnology、BMC Microbiology、BMC Biotechnology、Computational Biology and Chemistry等杂志审稿人


主要研究领域:

通过合成生物学及代谢工程方法,实现以大肠杆菌,酿酒酵母为平台的天然活性成分和大宗化学品的生产,主要研究方向包括:

1.天然活性成分及大宗化学品的生物合成与代谢调控;

2.酶工程;

3.非天然底物的生物利用。


获奖及荣誉:

2014    南京市领军型科技创业人才


科研项目:

作为负责人先后负责国家高技术研究发展“863”计划2项,国家自然科学基金项目1项,中央高校基本业务费2项,国家重点研发计划子课题2项,企业横向课题1项。

作为主要参与者先后参与长江学者创新团队、国家自然科学基金重点项目1项、面上项目3项。

主持项目:

2014年, 国家自然科学基金青年基金

2014年, 中央高校基本业务费1项

2014年, 国家“863”计划子课题1项

2015年, 国家“863”计划子课题1项

2015年, 中央高校基本业务费1项

2019年, 国家重点研发计划子课题2项

2019年, 企业横向课题1项


代表性著作:

1.Xiaolin Shen1, Jia Wang, Chenyi Li, Qipeng Yuan, Yajun Yan*. Dynamic gene expression engineering as a tool in pathway engineering. Current opinion in Biotechnology, 2019, 59, 122-129. (1区TOP, IF=8.383)
2.Xiaolin Shen1, Dayong Zhou, Yuheng Lin, Jia Wang, Shuaihua Gao, Palani Kandavelu, Hua Zhang, Ruihua Zhang, Bi-Cheng Wang, John Rose, Qipeng Yuan, Yajun Yan. Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli. Scientific Reports. 2019, 9, 7087-7097. (IF=4.122)
3.Xiaolin Shen1, Jia Wang1, Bradley K. Gall, Eric M. Ferreira, Qipeng Yuan*, Yajun Yan*. Establishment of novel biosynthetic pathways for the production of salicyl alcohol and gentisyl alcohol in engineered Escherichia coli. 并列一作,ACS Synthetic Biology, 2018, 7(4),1012-1017. (IF=5.382)
4.Jia Wang1, Xiaolin Shen1, Jian Wang, Yaping Yang, Qipeng Yuan*, Yajun Yan*. Exploring the promiscuity of phenol hydroxylase from Pseudomonas stutzeri OX1 for the biosynthesis of phenolic compounds. 并列一作,ACS Synthetic Biology, 2018, 7:1238-1243. (IF=5.382)
5.Xiaolin Shen1, Jia Wang, Jian Wang, Zhenya Chen, Qipeng Yuan*, Yajun Yan*. High-level De novo Biosynthesis of Arbutin in Engineered Escherichia coli. Metabolic Engineering, 2017, 42, 52-58. (1区TOP, IF=8.201)
6.Xiaolin Shen1, Monika Mahajani1, Jia Wang, Yaping Yang, Qipeng Yuan, Yajun Yan*, Yuheng Lin*. Elevating 4-Hydroxycoumarin Production through Alleviating Thioesterase- mediated Salicoyl-CoA Degradation. 并列一作,Metabolic Engineering, 2017, 42, 59-65. (1区TOP, IF=8.201)
7.Jia Wang, Xiaolin Shen*. Engineering Microbial Metabolism for Chemical Synthesis – Reviews and Perspectives. Chapter 2: Citric Acid Cycle and Its Metabolic Engineering Applications. (专著,通讯作者)
8.Xinxiao Sun1, Xiaolin Shen1, Rachit Jain, Yuheng Lin, Jian Wang, Jing Sun, Jia Wang, Yajun Yan*, Qipeng Yuan*. Synthesis of Chemicals by Metabolic Engineering of Microbes. Chemical Society Reviews,2015, 44, 3760-3785.(IF=33.383)
9.Jing Sun1, Yuheng Lin1, Xiaolin Shen1, Rachit Jain, Xinxiao Sun, Qipeng Yuan, Yajun Yan. Aerobic biosynthesis of hydrocinnamicacids in Escherichia coli with a strictly oxygen-sensitive enoate reductase. Metabolic Engineering, 2016, 35: 75-82. (1区TOP, IF=8.201)
10.Xiaolin Shen, Yuheng Lin, Rachit Jain, Qipeng Yuan, Yajun Yan*. Inhibition of acetate accumulation leads to enhanced production of (R,R)-2,3-butanediol from glycerol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology, 2012, 39(11),1725-1729. 
11.Yuheng Lin, Xiaolin Shen, Qipeng Yuan & Yajun Yan. Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin. Nature Communications. 2013, DOI: 10.1038/ncomms3603. (IF=12.353)

教师寄语:

纸上得来终觉浅,绝知此事要躬行。


招生要求:

善于思考,踏实努力,执行力强。