朱绍洲

发布时间:2019-10-31

 

姓名:朱绍洲

 

职称:讲师

 

邮箱:zhusz@mail.buct.edu.cn

 

办公地址:科技大厦301-2


教育背景:

2012/09-2016/07      Philipps-Universität Marburg Department of ChemistryPhD

2009/09-2012/07     足球投注,足球外围平台,硕士

2005/09-2009/07     山东大学,海洋学院,学士


工作经历:

2016/09-至今  足球外围平台,讲师,硕士生导师


主要研究领域:

1.核糖体多肽类复杂抗生素的生物合成

2.生物催化

3.生物大分子拓扑结构


科研项目:

主持项目:

2016年, 中央高校基本业务费1

2017年, 国家自然科学基金青年基金

2019年, 国家重点研发计划课题1


代表性著作:

30.          Li H, Gao S, Qiu Y, Liang C, Zhu S, Zheng G. 2019. Genome mining integrating semi-rational protein engineering and nanoreactor design: roadmap for a robust biocatalyst for industrial resolution of Vince lactam. Applied Microbiology and Biotechnology.(通讯作者)

29.          Hu J, Li G, Shams S, Zhu S, Zheng G. 2019. Stereoselective synthesis of the key intermediate of ticagrelor and its diverse analogs using a new alcohol dehydrogenase from Rhodococcus kyotonensis. Process Biochemistry. (通讯作者)

28.          Zhu S, Su Y, Shams S, Feng Y, Tong Y, Zheng G. 2019. Lassomycin and lariatin lasso peptides as suitable antibiotics for combating mycobacterial infections: current state of biosynthesis and perspectives for production. Applied Microbiology and Biotechnology 103:3931-3940.

27.          Su Y, Han M, Meng X, Feng Y, Luo S, Yu C, Zheng G, Zhu S. 2019. Discovery and characterization of a novel C-terminal peptide carboxyl methyltransferase in a lassomycin-like lasso peptide biosynthetic pathway. Applied Microbiology and Biotechnology 103:2649-2664. (通讯作者)

26.          Ren H, Zhu S, Zheng G. 2019. Nanoreactor Design Based on Self-Assembling Protein Nanocages. International Journal of Molecular Sciences 20:592. (通讯作者)

25.          Li H, Qiu Y, Guo C-X, Han M, Zhou Y, Feng Y, Luo S-Z, Tong Y, Zheng G, Zhu S. 2019. Pyrroloindoline cyclization in tryptophan-containing cyclodipeptides mediated by an unprecedented indole C3 methyltransferase from Streptomyces sp. HPH0547. Chemical Communications. 55(58):8390-8393 (通讯作者)

24.          Zhu S, Zheng G. 2018. Dynamic kinetic resolution of Vince lactam catalyzed by γ-lactamases: a mini-review. Journal of Industrial Microbiology & Biotechnology 45:1017-1031.

23.          Zhu S, Zheng G. 2018. Transcription-factor centric genome mining strategy for discovery of diverse unprecedented RiPP gene clusters. bioRxiv:467670.

22.          Zhu S, Shi Y, Zhang X, Zheng G. 2018. Biocatalytic Asymmetric Synthesis of (1R, 2S)-N-Boc-vinyl-ACCA Ethyl Ester with a Newly Isolated Sphingomonas aquatilis. Applied Biochemistry and Biotechnology 184:500-512.

21.          Li H, Zhu S, Zheng G. 2018. Promiscuous (+)-γ-lactamase activity of an amidase from nitrile hydratase pathway for efficient synthesis of carbocyclic nucleosides intermediate. Bioorganic & Medicinal Chemistry Letters 28:1071-1076. (通讯作者)

20.          Li H, Zheng G, Zhu S. 2018. Construction of an organelle-like nanodevice via supramolecular self-assembly for robust biocatalysts. Microbial Cell Factories 17:26. (通讯作者)

19.          Gao S, Zhu S, Huang R, Li H, Wang H, Zheng G. 2018. Engineering the Enantioselectivity and Thermostability of a (+)-γ-Lactamase from Microbacterium hydrocarbonoxydans for Kinetic Resolution of Vince Lactam (2-Azabicyclo [2.2. 1] hept-5-en-3-one). Appl. Environ. Microbiol. 84:e01780-01717.

18.          Xu T, Wang C, Zhu S, Zheng G. 2017. Enzymatic preparation of optically pure t-butyl 6-chloro-(3R, 5S)-dihydroxyhexanoate by a novel alcohol dehydrogenase discovered from Klebsiella oxytoca. Process Biochemistry 57:72-79. (通讯作者)

17.          Zhu S, Huang R, Gao S, Li X, Zheng G. 2016. Discovery and characterization of a second extremely thermostable (+)-γ-lactamase from Sulfolobus solfataricus P2. Journal of Bioscience and Bioengineering 121:484-490.

16.          Zhu S, Hegemann JD, Fage CD, Zimmermann M, Xie X, Linne U, Marahiel MA. 2016. Insights into the unique phosphorylation of the lasso peptide paeninodin. Journal of Biological Chemistry 291:13662-13678.

15.          Zhu S, Fage CD, Hegemann JD, Yan D, Marahiel MA. 2016. Dual substrate‐controlled kinase activity leads to polyphosphorylated lasso peptides. FEBS Letters 590:3323-3334.

14.          Zhu S, Fage CD, Hegemann JD, Mielcarek A, Yan D, Linne U, Marahiel MA. 2016. The B1 protein guides the biosynthesis of a lasso peptide. Scientific Reports 6:35604.

13.          Hegemann JD, Fage CD, Zhu S, Harms K, Di Leva FS, Novellino E, Marinelli L, Marahiel MA. 2016. The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II. Molecular BioSystems 12:1106-1109.

12.          Gao S, Huang R, Zhu S, Li H, Zheng G. 2016. Identification and characterization of a novel (+)-γ-lactamase from Microbacterium hydrocarbonoxydans. Applied Microbiology and Biotechnology 100:9543-9553.

11.          Fage CD, Hegemann JD, Nebel AJ, Steinbach RM, Zhu S, Linne U, Harms K, Bange G, Marahiel MA. 2016. Structure and mechanism of the sphingopyxin I lasso peptide isopeptidase. Angewandte Chemie International Edition 55:12717-12721.

10.          Ren L, Zhu S, Shi Y, Gao S, Zheng G. 2015. Enantioselective resolution of γ-lactam by a novel thermostable type II (+)-γ-lactamase from the hyperthermophilic archaeon Aeropyrum pernix. Applied Biochemistry and Biotechnology 176:170-184.

9.            Gao S, Zhu S, Huang R, Lu Y, Zheng G. 2015. Efficient synthesis of the intermediate of abacavir and carbovir using a novel (+)-γ-lactamase as a catalyst. Bioorganic & Medicinal Chemistry Letters 25:3878-3881.

8.            Zhu S, Ren L, Yu S, Gong C, Song D, Zheng G. 2014. Enzymatic preparation of optically pure (+)-2-azabicyclo [2.2. 1] hept-5-en-3-one by (-)-γ-lactamase from Bradyrhizobium japonicum USDA 6. Bioorganic & Medicinal Chemistry Letters 24:4899-4902.

7.            Song D, Zhu S, Li X, Zheng G. 2014. Homology modeling and docking studies of BjGL, a novel (+) gamma-lactamase from Bradyrhizobium japonicum. Journal of Molecular Graphics and Modelling 47:1-7.

6.            Hegemann JD, Zimmermann M, Zhu S, Steuber H, Harms K, Xie X, Marahiel MA. 2014. Xanthomonins I–III: A New Class of Lasso Peptides with a Seven‐Residue Macrolactam Ring. Angewandte Chemie International Edition 53:2230-2234.

5.            Zhu S, Song D, Gong C, Tang P, Li X, Wang J, Zheng G. 2013. Biosynthesis of nucleoside analogues via thermostable nucleoside phosphorylase. Applied Microbiology and Biotechnology 97:6769-6778.

4.            Zhu S, Gong C, Ren L, Li X, Song D, Zheng G. 2013. A simple and effective strategy for solving the problem of inclusion bodies in recombinant protein technology: His-tag deletions enhance soluble expression. Applied Microbiology and Biotechnology 97:837-845.

3.            Hegemann JD, Zimmermann M, Zhu S, Klug D, Marahiel MA. 2013. Lasso peptides from proteobacteria: genome mining employing heterologous expression and mass spectrometry. Peptide Science 100:527-542.

2.            Zhu S, Ren L, Wang J, Zheng G, Tang P. 2012. Two-step efficient synthesis of 5-methyluridine via two thermostable nucleoside phosphorylase from Aeropyrum pernix. Bioorganic & Medicinal Chemistry Letters 22:2102-2104.

1.            Zhu S, Gong C, Song D, Gao S, Zheng G. 2012. Discovery of a novel (+)-γ-lactamase from Bradyrhizobium japonicum USDA 6 by rational genome mining. Appl. Environ. Microbiol. 78:7492-7495.


教师寄语:

放弃不难,但坚持一定很酷


招生要求:

诚信,善良,勤奋